Drug Information

Drug General Information
Drug ID
DX5YOI
Drug Name
N-(4-(morpholinosulfonyl)phenyl)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine
Synonyms
CHEMBL1801110
Indication Discovery agent Investigative [1587926]
Formula
C19H19N7O3S
Canonical SMILES
O=S(=O)(N1CCOCC1)c2ccc(Nc3nccn4c(cnc34)c5cn[nH]c5)cc2
InChI
InChI=1S/C19H19N7O3S/c27-30(28,25-7-9-29-10-8-25)16-3-1-15(2-4-16)24-18-19-21-13-17(14-11-22-23-12-14)26(19)6-5-20-18/h1-6,11-13H,7-10H2,(H,20,24)(H,22,23)
InChIKey
ZFOPWBXSJXQVFA-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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