Drug Information

Drug General Information
Drug ID
DX5YFU
Drug Name
Oxo-{2-[4-(phenyl-lambda*4*-sulfanyl)-benzenesulfonyl]-1,2,3,4-tetrahydro-isoquinolin-3-yl}-acetic acid
Synonyms
CHEMBL137929
Indication Discovery agent Investigative [1587926]
Formula
C23H19NO5S2
Canonical SMILES
OC(=O)C(=O)C1Cc2ccccc2CN1S(=O)(=O)c3ccc(Sc4ccccc4)cc3
InChI
InChI=1S/C23H19NO5S2/c25-22(23(26)27)21-14-16-6-4-5-7-17(16)15-24(21)31(28,29)20-12-10-19(11-13-20)30-18-8-2-1-3-9-18/h1-13,21H,14-15H2,(H,26,27)
InChIKey
VOORVZQGMACJHE-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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