Drug Information

Drug General Information
Drug ID
DX3SYQ
Drug Name
2-(4'-Chloro-biphenyl-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide
Synonyms
CHEMBL141673
Indication Discovery agent Investigative [1587926]
Formula
C22H19ClN2O4S
Canonical SMILES
ONC(=O)C1Cc2ccccc2CN1S(=O)(=O)c3ccc(cc3)c4ccc(Cl)cc4
InChI
InChI=1S/C22H19ClN2O4S/c23-19-9-5-15(6-10-19)16-7-11-20(12-8-16)30(28,29)25-14-18-4-2-1-3-17(18)13-21(25)22(26)24-27/h1-12,21,27H,13-14H2,(H,24,26)
InChIKey
GSLSWNSJTMLFSO-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.