Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX3KLE
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| Drug Name |
N-(3,5-bis(trifluoromethyl)phenyl)-1-methyl-4-(pyridin-4-ylmethylamino)-1H-pyrazole-5-carboxamide
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| Synonyms |
CHEMBL241313
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C19H15F6N5O
|
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| Canonical SMILES |
Cn1ncc(NCc2ccncc2)c1C(=O)Nc3cc(cc(c3)C(F)(F)F)C(F)(F)F
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| InChI |
InChI=1S/C19H15F6N5O/c1-30-16(15(10-28-30)27-9-11-2-4-26-5-3-11)17(31)29-14-7-12(18(20,21)22)6-13(8-14)19(23,24)25/h2-8,10,27H,9H2,1H3,(H,29,31)
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| InChIKey |
TVJVGUKOYAEUMF-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Vascular endothelial growth factor receptor 1 | Target Info | [1587926] | |||
| KEGG Pathway | Ras signaling pathway | ||||
| Rap1 signaling pathway | |||||
| Cytokine-cytokine receptor interaction | |||||
| Endocytosis | |||||
| PI3K-Akt signaling pathway | |||||
| VEGF signaling pathway | |||||
| Focal adhesion | |||||
| Proteoglycans in cancerhsa04014:Ras signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Transcriptional misregulation in cancer | |||||
| Rheumatoid arthritis | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathway | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY networkglypican_1pathway:Glypican 1 network | |||||
| S1P3 pathway | |||||
| VEGFR1 specific signals | |||||
| References | |||||
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