Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX2GUA
|
||||
| Drug Name |
1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}urea
|
||||
| Synonyms |
CHEMBL437876
|
||||
| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C31H26F4N6O2
|
||||
| Canonical SMILES |
CCCn1c2ccc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)cc2c4c5CNC(=O)c5c6c(CCc7nn(C)cc67)c14
|
||||
| InChI |
InChI=1S/C31H26F4N6O2/c1-3-10-41-24-9-5-16(37-30(43)38-23-11-15(31(33,34)35)4-7-21(23)32)12-18(24)26-19-13-36-29(42)27(19)25-17(28(26)41)6-8-22-20(25)14-40(2)39-22/h4-5,7,9,11-12,14H,3,6,8,10,13H2,1-2H3,(H,36,42)(H2,37,38,43)
|
||||
| InChIKey |
CXHWRPKRHUOABU-UHFFFAOYSA-N
|
||||
| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Angiopoietin 1 receptor | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling PathwayNetPath_8:Wnt Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathwayP00005:Angiogenesis | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling | |||||
| References | |||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.