Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX1ZAU
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| Drug Name |
(S)-5-(2-(2-aminopyrimidin-5-yl)ethynyl)-2-fluoro-N-(2-(3-(methylamino)piperidin-1-yl)-5-(trifluoromethyl)phenyl)benzamide
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| Synonyms |
CHEMBL220532
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C26H24F4N6O
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| Canonical SMILES |
CN[C@H]1CCCN(C1)c2ccc(cc2NC(=O)c3cc(ccc3F)C#Cc4cnc(N)nc4)C(F)(F)F
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| InChI |
InChI=1S/C26H24F4N6O/c1-32-19-3-2-10-36(15-19)23-9-7-18(26(28,29)30)12-22(23)35-24(37)20-11-16(6-8-21(20)27)4-5-17-13-33-25(31)34-14-17/h6-9,11-14,19,32H,2-3,10,15H2,1H3,(H,35,37)(H2,31,33,34)/t19-/m0/s1
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| InChIKey |
YNUAYENQUDYECY-IBGZPJMESA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Angiopoietin 1 receptor | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling PathwayNetPath_8:Wnt Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathwayP00005:Angiogenesis | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling | |||||
| References | |||||
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