Drug Information
| Drug General Information | |||||
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| Drug ID |
DX1EBL
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| Drug Name |
3-{3-butyl-19-methyl-14-oxo-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}-1-(4-methoxyphenyl)urea
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| Synonyms |
CHEMBL374736
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C32H32N6O3
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| Canonical SMILES |
CCCCn1c2ccc(NC(=O)Nc3ccc(OC)cc3)cc2c4c5CNC(=O)c5c6c(CCc7nn(C)cc67)c14
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| InChI |
InChI=1S/C32H32N6O3/c1-4-5-14-38-26-13-8-19(35-32(40)34-18-6-9-20(41-3)10-7-18)15-22(26)28-23-16-33-31(39)29(23)27-21(30(28)38)11-12-25-24(27)17-37(2)36-25/h6-10,13,15,17H,4-5,11-12,14,16H2,1-3H3,(H,33,39)(H2,34,35,40)
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| InChIKey |
WLQXMZGRKAHBAE-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Angiopoietin 1 receptor | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling PathwayNetPath_8:Wnt Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathwayP00005:Angiogenesis | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling | |||||
| References | |||||
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