Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0ZY3E
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| Former ID |
DCL000136
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| Drug Name |
INO-1001
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| Synonyms |
Hypoxanthine arabinoside; LT00454797; 9-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
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| Drug Type |
Small molecular drug
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| Therapeutic Class |
Anticancer Agents
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| Company |
Inotek Pharma.
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| Structure |
|
Download2D MOL |
|||
| Formula |
C10H12N4O5
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| Canonical SMILES |
C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)CO)O)O
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| InChI |
1S/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18)/t4-,6-,7-,10?/m1/s1
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| InChIKey |
UGQMRVRMYYASKQ-VTHZCTBJSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
11341956, 11362139, 11364855, 11367417, 11369979, 11372318, 11375508, 11378147, 11485713, 11487541, 11489755, 11490975, 11493609, 11495724, 26613325, 26679890, 43328346, 48094522, 48169347, 80900411, 83548623, 92710479, 114937692, 121362243, 124637303, 126631840, 126658140, 135985675, 144076071, 152099856, 162173203, 179039799, 223399182, 226874784
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| SuperDrug ATC ID |
C03CA03
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| SuperDrug CAS ID |
cas=055837279
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| Target and Pathway | |||||
| Target(s) | Poly ADP ribose polymerase (PARP) | Target Info | Modulator | [527044], [530857] | |
| References | |||||
| Ref 527044 | INO-1001 a novel poly(ADP-ribose) polymerase (PARP) inhibitor improves cardiac and pulmonary function after crystalloid cardioplegia and extracorporal circulation. Shock. 2004 May;21(5):426-32. | ||||
| Ref 530857 | Therapeutic injection of PARP inhibitor INO-1001 preserves cardiac function in porcine myocardial ischemia and reperfusion without reducing infarct size. Shock. 2010 May;33(5):507-12. | ||||
| Ref 527044 | INO-1001 a novel poly(ADP-ribose) polymerase (PARP) inhibitor improves cardiac and pulmonary function after crystalloid cardioplegia and extracorporal circulation. Shock. 2004 May;21(5):426-32. | ||||
| Ref 530857 | Therapeutic injection of PARP inhibitor INO-1001 preserves cardiac function in porcine myocardial ischemia and reperfusion without reducing infarct size. Shock. 2010 May;33(5):507-12. | ||||
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