Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0ZX2D
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| Former ID |
DIB006154
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| Drug Name |
11C-6-Me-BTA-1
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| Synonyms |
Carbon-11-6-Me-BTA-1; 11C-BTA-1
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| Indication | Alzheimer disease [ICD9: 331; ICD10:G30] | Phase 1 | [1] | ||
| Company |
University of Pittsburgh
|
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
c1(nc2c(s1)cc(cc2)C)c1ccc(N[11CH3])cc1
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| CAS Number |
CAS 370099-48-2
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| Target and Pathway | |||||
| Target(s) | Amyloid beta A4 protein | Target Info | Modulator | [2] | |
| KEGG Pathway | Notch signaling pathway | ||||
| Alzheimer's disease | |||||
| Reactome | Nuclear signaling by ERBB4 | ||||
| Degradation of the extracellular matrix | |||||
| Regulated proteolysis of p75NTR | |||||
| NRIF signals cell death from the nucleus | |||||
| Activated NOTCH1 Transmits Signal to the Nucleus | |||||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
| EPH-ephrin mediated repulsion of cells | |||||
| WikiPathways | Notch Signaling Pathway | ||||
| Signaling by ERBB4 | |||||
| Signaling by NOTCH3 | |||||
| Signaling by NOTCH4 | |||||
| Signaling by NOTCH1 | |||||
| Signaling by NOTCH2 | |||||
| Notch Signaling Pathway | |||||
| Alzheimers Disease | |||||
| Signalling by NGF | |||||
| References | |||||
| REF 1 | List of drugs in development for neurodegenerative diseases: update October 2011. Neurodegener Dis. 2012;9(4):210-83. | ||||
| REF 2 | Radiosynthesis and evaluation of [11C]BTA-1 and [11C]3'-Me-BTA-1 as potential radiotracers for in vivo imaging of beta-amyloid plaques. Nuklearmedizin. 2007;46(6):271-80. | ||||
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