Drug Information

Drug General Information
Drug ID
D0ZU6O
Former ID
DNC001401
Drug Name
T-1106
Drug Type
Small molecular drug
Indication Viral infections [ICD9: 054.0, 054.1, 054.2, 054.3, 075, 771.2, 052, 053; ICD10:B01, B02, A60, B00, B27, G05.1, P35.2] Investigative [536317], [536620], [536903]
Structure
Download
2D MOL

3D MOL
Formula
C10H13N3O6
Canonical SMILES
C1=CN(C(=O)C(=N1)C(=O)N)C2C(C(C(O2)CO)O)O
InChI
1S/C10H13N3O6/c11-8(17)5-9(18)13(2-1-12-5)10-7(16)6(15)4(3-14)19-10/h1-2,4,6-7,10,14-16H,3H2,(H2,11,17)/t4-,6-,7-,10-/m1/s1
InChIKey
XVXWUBIIHFDOJO-KQYNXXCUSA-N
PubChem Compound ID
5271819
PubChem Substance ID
7837605, 8613596, 14799292, 14872665, 39282063, 75582744, 103567241, 113893456, 134340463, 134340588, 140218117, 143350501, 223816305, 232112873, 247741172
Target and Pathway
Target(s) RNA-dependentRNA polymerase Target Info Inhibitor [536317], [536620], [536903]
References
Ref 536317Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25.
Ref 536620PA subunit of RNA polymerase as a promising target for anti-influenza virus agents. Antiviral Res. 2008 Jun;78(3):194-201. Epub 2008 Jan 17.
Ref 536903Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106. Antimicrob Agents Chemother. 2009 Jan;53(1):202-9. Epub 2008 Oct 27.
Ref 536317Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25.
Ref 536620PA subunit of RNA polymerase as a promising target for anti-influenza virus agents. Antiviral Res. 2008 Jun;78(3):194-201. Epub 2008 Jan 17.
Ref 536903Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106. Antimicrob Agents Chemother. 2009 Jan;53(1):202-9. Epub 2008 Oct 27.

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