Drug Information
Drug General Information | |||||
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Drug ID |
D0Z9VY
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Former ID |
DCL000016
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Drug Name |
UCN-01
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Synonyms |
UCN; UCN01; Ucn 01; KRX-0601; KW-2401; UCN-02; (5s,6r,7r,9r,16r)-16-hydroxy-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5h,14h-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one; 7-Hydroxystaurosporine; 7-hydroxystaurosporine (UCN-01)
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Drug Type |
Small molecular drug
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Indication | Non-small cell lung cancer [ICD10:C33-C34] | Phase 2 | [521597] | ||
Therapeutic Class |
Anticancer Agents
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Company |
Keryx BioPharma.
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Structure |
Download2D MOL |
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Formula |
C28H26N4O4
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Canonical SMILES |
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C5<br />3)C(NC6=O)O)NC)OC
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InChI |
1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27-,28+/m1/s1
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InChIKey |
PBCZSGKMGDDXIJ-HQCWYSJUSA-N
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CAS Number |
CAS 112953-11-4
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PubChem Compound ID | |||||
PubChem Substance ID |
499504, 597067, 828000, 828774, 829609, 7890973, 7980340, 11417349, 12014075, 14834856, 14859145, 43128463, 46392797, 46517284, 49965093, 53789227, 57318623, 75855760, 93575990, 103073266, 103083413, 104252674, 117623524, 131269002, 134338729, 135030252, 139892065, 143298032, 163685599, 198960442, 227749464, 247172087, 249565590
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Target and Pathway | |||||
Pathway Interaction Database | Fanconi anemia pathway | ||||
p73 transcription factor network | |||||
ATR signaling pathway | |||||
Circadian rhythm pathway | |||||
p53 pathway | |||||
Reactome | Activation of ATR in response to replication stress | ||||
Processing of DNA double-strand break ends | |||||
Presynaptic phase of homologous DNA pairing and strand exchange | |||||
G2/M DNA damage checkpoint | |||||
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | |||||
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | |||||
References | |||||
Ref 535584 | UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1. Cancer Res. 2002 Oct 15;62(20):5743-8. | ||||
Ref 537127 | Cyclin-dependent kinase inhibitors as potential targeted anticancer agents. Invest New Drugs. 2009 Mar 5. | ||||
Ref 537231 | CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors. Mol Cancer. 2009 Apr 16;8:24. | ||||
Ref 537385 | Characterization of an inhibitory dynamic pharmacophore for the ERCC1-XPA interaction using a combined molecular dynamics and virtual screening approach. J Mol Graph Model. 2009 May 3. | ||||
Ref 537458 | The PI3K/Akt pathway as a target in the treatment of hematologic malignancies. Anticancer Agents Med Chem. 2009 Jun;9(5):550-9. |
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