Drug General Information
Drug ID	D0Z6TG
Drug Name	ZD-6021
Synonyms	ZD-6021; 255049-08-2; ZD-6021
Drug Type	Small molecular drug
Indication	Unspecified		Investigative	[1559815], [1560297]
Structure		Download 2D MOL 3D MOL
Formula	C35H35Cl2N3O2S
PubChem Compound ID	9895516
Target and Pathway
Target(s)	Substance-P receptor	Target Info	Modulator
	NK-2 receptor	Target Info	Modulator
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Measleshsa04020:Calcium signaling pathway
PANTHER Pathway	CCKR signaling map ST
Reactome	G alpha (q) signalling eventsR-HSA-416476:G alpha (q) signalling events
WikiPathways	SIDS Susceptibility Pathways
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signalingWP2664:Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR downstream signaling
References
Ref 1559815	Molecular cloning, mutations and effects of NK1 receptor antagonists reveal the human-like pharmacology of gerbil NK1 receptors.Biochem Pharmacol.2007 Jan 15;73(2):259-69.
Ref 1560297	Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors.

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