Drug General Information
Drug ID
D0Z4UN
Former ID
DAP000594
Drug Name
Pimecrolimus
Synonyms
Elidel; ASM 981; SDZ ASM 981; ASM-981; ASM-998; Elidel (TN); SDZ-ASM 981; Pimecrolimus [USAN:INN:BAN]; SDZ-ASM-981; Pimecrolimus (JAN/USAN/INN); 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone; 33-epi-Chloro-33-desoxyascomycin
Drug Type
Small molecular drug
Indication Atopic dermatitis [ICD9: 691.8, 692.9; ICD10:L00-L99] Approved [536054], [541863]
Therapeutic Class
Dermatologic Agents
Company
Norvatis Phamaceuticals Corporation
Structure
Download
2D MOL

3D MOL

Formula
C43H68ClNO11
InChI
InChI=1S/C43H68ClNO11/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)45-16-12-11-13-32(45)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-31(44)35(22-29)52-7/h18,20,25,27-33,35-39,46,51H,10-17,19,21-23H2,1-9H3/b24-18+,26-20+/t25-,27+,28+,29-,30+,31-,32-,33-,35+,36-,37-,38+,39+,43+/m0/s1
InChIKey
KASDHRXLYQOAKZ-XDSKOBMDSA-N
CAS Number
CAS 137071-32-0
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
D11AH02
Target and Pathway
Target(s) Calcineurin Target Info Inhibitor [537428]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Oocyte meiosis
Apoptosis
Wnt signaling pathway
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Long-term potentiation
Glutamatergic synapse
Dopaminergic synapse
Oxytocin signaling pathway
Glucagon signaling pathway
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Amphetamine addiction
Tuberculosis
HTLV-I infection
Reactome DARPP-32 events
FCERI mediated Ca+2 mobilization
Ca2+ pathway
WikiPathways Mitochondrial Gene Expression
MAPK Signaling Pathway
G Protein Signaling Pathways
Cardiac Hypertrophic Response
Fc epsilon receptor (FCERI) signaling
Signaling by the B Cell Receptor (BCR)
T-Cell Receptor and Co-stimulatory Signaling
Amyotrophic lateral sclerosis (ALS)
Spinal Cord Injury
Alzheimers Disease
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
Opioid Signalling
MicroRNAs in cardiomyocyte hypertrophy
Physiological and Pathological Hypertrophy of the Heart
References
Ref 536054Emerging drugs for moderate-to-severe psoriasis. Expert Opin Emerg Drugs. 2005 Feb;10(1):35-52.
Ref 541863(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6783).
Ref 537428Treatment of chronic blepharokeratoconjunctivitis with local calcineurin inhibitors. Ophthalmologe. 2009 Jul;106(7):635-8.

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