Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0Z3KA
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| Former ID |
DNC014542
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| Drug Name |
THIOCOLCHICINE
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [534060] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C22H25NO5S
|
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| Canonical SMILES |
CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)SC)OC)OC)OC
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| InChI |
1S/C22H25NO5S/c1-12(24)23-16-8-6-13-10-18(26-2)21(27-3)22(28-4)20(13)14-7-9-19(29-5)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
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| InChIKey |
CMEGANPVAXDBPL-INIZCTEOSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Tubulin beta | Target Info | Inhibitor | [534060] | |
| Tubulin | Target Info | Inhibitor | [534060] | ||
| PANTHER Pathway | Cytoskeletal regulation by Rho GTPase | ||||
| Huntington disease | |||||
| References | |||||
| Ref 534060 | J Med Chem. 1993 Mar 5;36(5):544-51.Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents. | ||||
| Ref 534060 | J Med Chem. 1993 Mar 5;36(5):544-51.Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents. | ||||
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