Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0YP7L
|
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| Former ID |
DNC003585
|
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| Drug Name |
SB-269970
|
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| Drug Type |
Small molecular drug
|
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| Indication | Sleep disorders [ICD9: 307.4, 327, 780.5; ICD10:F51, G47] | Terminated | [1], [2] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C18H28N2O3S
|
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| InChI |
InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1
|
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| InChIKey |
HWKROQUZSKPIKQ-MRXNPFEDSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
11114150, 11646537, 14827849, 14852068, 43224626, 47944892, 50104910, 77543877, 90340608, 103197548, 103995564, 114638177, 124750207, 134221723, 134340790, 135261782, 136367793, 137955553, 142785885, 172919549, 178100289, 178100296, 210275223, 210280862, 223394130, 223556755, 223702874, 226707028, 241383851, 242176196, 246475623, 249615589, 249855013, 250225791, 251971167, 252074169, 252212987, 252434592, 252474530
|
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| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 7 receptor | Target Info | Modulator | ||
| KEGG Pathway | Ras signaling pathway | ||||
| Calcium signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| PathWhiz Pathway | Excitatory Neural Signalling Through 5-HTR 7 and Serotonin | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3233). | ||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017732) | ||||
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