Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0YP0C
|
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| Former ID |
DIB009081
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| Drug Name |
DT-TX-30
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| Synonyms |
DT-TX-30-SE
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| Indication | Angina pectoris [ICD9: 413; ICD10:I20] | Phase 1 | [1] | ||
| Company |
Boehringer Ingelheim Corp
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
S(=O)(=O)(c1ccc(cc1)Cl)NCCc1ccc(/C(=C\CCCC(=O)O)/c2cncc<br />c2)cc1
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| CAS Number |
CAS 127369-68-0
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| Target and Pathway | |||||
| Target(s) | Thromboxane A2 receptor | Target Info | Antagonist | [1] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Platelet activation | |||||
| Reactome | Prostanoid ligand receptors | ||||
| G alpha (q) signalling events | |||||
| G alpha (12/13) signalling events | |||||
| Thromboxane signalling through TP receptor | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Small Ligand GPCRs | |||||
| Signal amplification | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | DTTX30, a combined thromboxane receptor antagonist and thromboxane synthetase inhibitor, prevents coronary thrombosis in anesthetized dogs. Basic Res Cardiol. 1997 Jun;92(3):181-90. | ||||
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