Drug General Information
Drug ID
D0Y9HH
Former ID
DNC001325
Drug Name
SIB-1508Y
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Terminated [525768], [529637]
Structure
Download
2D MOL

3D MOL

Formula
C12H14N2
Canonical SMILES
CN1CCCC1C2=CN=CC(=C2)C#C
InChI
1S/C12H14N2/c1-3-10-7-11(9-13-8-10)12-5-4-6-14(12)2/h1,7-9,12H,4-6H2,2H3
InChIKey
NUPUDYKEEJNZRG-UHFFFAOYSA-N
CAS Number
CAS 192231-16-6
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Nicotinic ACh receptor alpha 4/beta 2 Target Info Modulator
References
Ref 525768Recombinant human receptors and functional assays in the discovery of altinicline (SIB-1508Y), a novel acetylcholine-gated ion channel (nAChR) agonist. Pharm Acta Helv. 2000 Mar;74(2-3):125-30.
Ref 529637Pharmacological characterization of (S)-(2)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine HCl (SIB-1508Y, Altinicline), a novel nicotinic acetylcholine receptor agonist. Brain Res. 2008 Oct 9;1234:16-24.

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