Drug Information

Drug General Information
Drug ID
D0Y8UP
Former ID
DNC014645
Drug Name
2-Furan-2-yl-7-methyl-1H-[1,8]naphthyridin-4-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [525604]
Structure
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2D MOL

3D MOL
Formula
C13H10N2O2
Canonical SMILES
CC1=NC2=C(C=C1)C(=O)C=C(N2)C3=CC=CO3
InChI
1S/C13H10N2O2/c1-8-4-5-9-11(16)7-10(15-13(9)14-8)12-3-2-6-17-12/h2-7H,1H3,(H,14,15,16)
InChIKey
INGWEZCOABYORO-UHFFFAOYSA-N
PubChem Compound ID
13285535
Target and Pathway
Target(s) Tubulin Target Info Inhibitor [525604]
Tubulin beta Target Info Inhibitor [525604]
KEGG Pathway Phagosome
Gap junction
Pathogenic Escherichia coli infection
NetPath Pathway FSH Signaling Pathway
TCR Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Cytoskeletal regulation by Rho GTPase
Huntington disease
Reactome Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization?from the centrosome
Anchoring of the basal body to the plasma membrane
WikiPathways Parkin-Ubiquitin Proteasomal System pathway
Pathogenic Escherichia coli infection
Mitotic G2-G2/M phases
References
Ref 525604J Med Chem. 1999 Oct 7;42(20):4081-7.Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Ref 525604J Med Chem. 1999 Oct 7;42(20):4081-7.Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

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