Drug Information

Drug General Information
Drug ID
D0Y8BW
Former ID
DIB008456
Drug Name
TMC-647055
Drug Type
Small molecular drug
Indication HCV infection [ICD9: 070.4, 070.5, 070.70; ICD10:B17.1, B18.2] Phase 1 [523173]
Company
Janssen research & development
Structure
Download
2D MOL

3D MOL
Formula
C32H38N4O6S
Canonical SMILES
CN1CCOCCN(S(=O)(=O)NC(=O)C2=CC3=C(C=C2)C(=C4N3CC(=CC5=C<br />4C=CC(=C5)OC)C1=O)C6CCCCC6)C
InChI
1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)
InChIKey
UOBYJVFBFSLCTQ-UHFFFAOYSA-N
PubChem Compound ID
44556044
PubChem Substance ID
87239490, 120090998, 138444879, 160700919, 162109046, 163672704, 198965293, 227469298, 246454798, 252216478, 252451639
Target and Pathway
Target(s) Hepatitis C virus NS5B polymerase Target Info Inhibitor [550180]
References
Ref 523173ClinicalTrials.gov (NCT01202825) TMC647055HPC1001 - First-in-human Trial to Examine Safety, Tolerability and Pharmacokinetics (How the Drug is Absorbed Into the Bloodstream) of Increasing Single OralDoses and of Increasing Repeated Oral Doses of TMC647055 in Healthy Volunteers and in Hepatitis C Virus Infected Patients. U.S. National Institutes of Health.
Ref 550180WO patent application no. 2014,1522,75, Deuterium modified derivatives of the ns5b polymerase inhibitor tmc647055.

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