Drug General Information
Drug ID	D0Y7XC
Former ID	DNC001406
Drug Name	Talipexole
Drug Type	Small molecular drug
Indication	Discovery agent		Phase 4	[524901], [540844]
Structure		Download 2D MOL 3D MOL
Formula	C10H15N3S
InChI	InChI=1S/C10H15N3S/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8/h2H,1,3-7H2,(H2,11,12)
InChIKey	DHSSDEDRBUKTQY-UHFFFAOYSA-N
PubChem Compound ID	5374
PubChem Substance ID	7685814, 7978785, 8153304, 15195713, 15220191, 26756524, 29224426, 47291277, 47365369, 50064065, 50111389, 57322742, 78146472, 85209826, 85788358, 96025243, 103185398, 103804992, 103936559, 104309056, 117520783, 124892407, 127736594, 135016613, 136352153, 137008078, 142950048, 144205573, 162256164, 162311028, 162768352, 163882631, 170466015, 178102093, 179149471, 184546073, 198978938, 210279143, 210281465, 226433459, 251916766, 251918005
Target and Pathway
Target(s)	D(2) dopamine receptor	Target Info	Agonist	[538017]
KEGG Pathway	Rap1 signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Alcoholism
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Hypothetical Network for Drug Addiction
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR ligand binding
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
References
Ref 524901	ClinicalTrials.gov (NCT02231905) Safety, Tolerability and Efficacy of Switching From Talipexole to Pramipexole in Patients With Parkinson's Disease. U.S. National Institutes of Health.
Ref 540844	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5442).
Ref 538017	Effects of talipexole on emesis-related changes in abdominal afferent vagal activity and ileal serotonin metabolism in rats. Res Commun Mol Pathol Pharmacol. 1997 Jan;95(1):67-82.

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