Drug General Information
Drug ID
D0Y6UB
Former ID
DNC000053
Drug Name
2-PMPA
Drug Type
Small molecular drug
Indication Discovery agent Terminated [546702]
Structure
Download
2D MOL

3D MOL

Formula
C6H11O7P
Canonical SMILES
C(CC(=O)O)C(CP(=O)(O)O)C(=O)O
InChI
1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11,12)13/h4H,1-3H2,(H,7,8)(H,9,10)(H2,11,12,13)
InChIKey
ISEYJGQFXSTPMQ-UHFFFAOYSA-N
CAS Number
CAS 380603-10-1
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Glutamate carboxypeptidase II Target Info Inhibitor [534932]
KEGG Pathway Alanine, aspartate and glutamate metabolism
Metabolic pathways
Vitamin digestion and absorption
NetPath Pathway TCR Signaling Pathway
TNFalpha Signaling Pathway
Reactome Amino acid synthesis and interconversion (transamination)
WikiPathways One Carbon Metabolism
References
Ref 546702Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009714)
Ref 534932Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury. Nat Med. 1999 Dec;5(12):1396-402.

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