| Drug General Information |
| Drug ID |
D0Y5TL
|
| Former ID |
DNC005808
|
| Drug Name |
ALLOXAZINE
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C10H6N4O2
|
| InChI |
InChI=1S/C10H6N4O2/c15-9-7-8(13-10(16)14-9)12-6-4-2-1-3-5(6)11-7/h1-4H,(H2,12,13,14,15,16)
|
| InChIKey |
HAUGRYOERYOXHX-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
451914, 473315, 4956928, 6156892, 7778045, 10523977, 10560890, 10589628, 11110697, 11216386, 11402151, 11657363, 15365357, 17404721, 17425201, 17425202, 24277695, 24890699, 25632054, 26753529, 39392322, 47331796, 48259515, 48259516, 48448037, 49645529, 50105899, 50105900, 53777264, 57362399, 80096949, 85083500, 85090530, 85208946, 85230889, 88297412, 88521338, 89449665, 90340898, 92220724, 92225576, 92303577, 99017118, 99226622, 103264398, 104839904, 105206877, 114174506, 121361102, 124504616
|
| Target and Pathway |
| Target(s) |
Adenosine A2b receptor |
Target Info |
Inhibitor |
[2]
|
|---|
| Adenosine A2a receptor |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
Rap1 signaling pathway
|
|
Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Vascular smooth muscle contraction
|
|
Alcoholismhsa04015:Rap1 signaling pathway
|
|
cAMP signaling pathway
|
|
Parkinson's disease
|
|
Alcoholism
|
|
NetPath Pathway
|
TGF_beta_Receptor Signaling Pathway
|
|
TCR Signaling Pathway
|
|
Pathway Interaction Database
|
C-MYB transcription factor networkhif2pathway:HIF-2-alpha transcription factor network
|
|
PathWhiz Pathway
|
Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
|
Reactome
|
Adenosine P1 receptors
|
|
G alpha (s) signalling events
|
|
Surfactant metabolismR-HSA-187024:NGF-independant TRKA activation
|
|
Surfactant metabolism
|
|
WikiPathways
|
Nucleotide GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
|
GPCR ligand binding
|
|
GPCR downstream signalingWP80:Nucleotide GPCRs
|
|
Monoamine Transport
|
|
NGF signalling via TRKA from the plasma membrane
|
|
GPCR downstream signaling
|
|
GPCRs, Other
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 456). |
|---|
| REF 2 | J Med Chem. 2005 Nov 3;48(22):6887-96.2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. |
|---|
