| Drug General Information |
| Drug ID |
D0Y4MC
|
| Former ID |
DIB018710
|
| Drug Name |
9-OH-risperidone
|
| Synonyms |
9-hydroxy-risperidone
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C23H27FN4O3
|
| InChI |
InChI=1S/C23H27FN4O3/c1-14-18(23(30)28-13-17(29)3-5-21(28)25-14)8-11-27-9-6-15(7-10-27)22-19-4-2-16(24)12-20(19)31-26-22/h2,4,12,15,17,29H,3,5-11,13H2,1H3
|
| InChIKey |
ABWPQNZPAOAQSG-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
631818, 10307962, 38927021, 47954520, 48029712, 50271697, 103128260, 104647614, 117584510, 127383724, 135649866, 138746068, 162309163, 162793832, 164227185, 164760976, 204381780, 224951789, 226562108
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 2A receptor |
Target Info |
Antagonist |
[2]
|
|---|
| 5-hydroxytryptamine 1A receptor |
Target Info |
Antagonist |
[2]
|
| 5-hydroxytryptamine 1D receptor |
Target Info |
Antagonist |
[2]
|
| 5-hydroxytryptamine 1E receptor |
Target Info |
Antagonist |
[2]
|
| Histamine H1 receptor |
Target Info |
Antagonist |
[2]
|
| 5-hydroxytryptamine 1B receptor |
Target Info |
Antagonist |
[2]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Gap junction
|
|
Serotonergic synapse
|
|
Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
|
|
Serotonergic synapsehsa04024:cAMP signaling pathway
|
|
Serotonergic synapsehsa04020:Calcium signaling pathway
|
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PANTHER Pathway
|
5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
5HT1 type receptor mediated signaling pathwayP04385:Histamine H1 receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
5HT1 type receptor mediated signaling pathway
|
|
Reactome
|
Serotonin receptors
|
|
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
|
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G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
|
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G alpha (i) signalling eventsR-HSA-390650:Histamine receptors
|
|
G alpha (i) signalling events
|
|
WikiPathways
|
Serotonin Receptor 2 and STAT3 Signaling
|
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Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
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SIDS Susceptibility Pathways
|
|
Monoamine GPCRs
|
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GPCRs, Class A Rhodopsin-like
|
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Gastrin-CREB signalling pathway via PKC and MAPK
|
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GPCR ligand binding
|
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GPCR downstream signaling
|
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GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
|
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GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
|
|
GPCR downstream signalingWP58:Monoamine GPCRs
|
|
IL-4 Signaling Pathway
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 67). |
|---|
| REF 2 | Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology (Berl). 1996 Mar;124(1-2):57-73. |
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