Drug Information

Drug General Information
Drug ID
D0Y4LI
Former ID
DIB018045
Drug Name
PF-4708671
Synonyms
PF4708671; PF 4708671
Drug Type
Small molecular drug
Indication Ulcerative colitis [ICD9: 556; ICD10:K51] Clinical trial [531100]
Structure
Download
2D MOL
Formula
C19H21F3N6
InChI
InChI=1S/C19H21F3N6/c1-2-13-10-23-12-24-18(13)28-7-5-27(6-8-28)11-17-25-15-4-3-14(19(20,21)22)9-16(15)26-17/h3-4,9-10,12H,2,5-8,11H2,1H3,(H,25,26)
InChIKey
FBLPQCAQRNSVHB-UHFFFAOYSA-N
PubChem Compound ID
51371303
PubChem Substance ID
121362084, 137275978, 162248888, 163726900, 163726902, 163726906, 163726909, 163726911, 163726913, 163726914, 164138939, 164178011, 164764188, 165247821, 172088844, 175612770, 196678888, 210275343, 210280991, 223391260, 223705216, 225373252, 241376772, 249565716, 252090100, 252157726, 252160289, 252451019, 252473011, 252543447
Target and Pathway
Target(s) Ribosomal protein S6 kinase Target Info Inhibitor [531100]
KEGG Pathway ErbB signaling pathway
HIF-1 signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
TGF-beta signaling pathway
Fc gamma R-mediated phagocytosis
Insulin signaling pathway
Proteoglycans in cancer
Acute myeloid leukemia
Choline metabolism in cancer
PANTHER Pathway Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
PDGF signaling pathway
PI3 kinase pathway
p53 pathway by glucose deprivation
CCKR signaling map ST
Pathway Interaction Database Insulin Pathway
IL4-mediated signaling events
CDC42 signaling events
Angiopoietin receptor Tie2-mediated signaling
Regulation of Telomerase
mTOR signaling pathway
IGF1 pathway
IL2 signaling events mediated by PI3K
Integrins in angiogenesis
RXR and RAR heterodimerization with other nuclear receptor
Signaling events mediated by Stem cell factor receptor (c-Kit)
a6b1 and a6b4 Integrin signaling
TGF-beta receptor signaling
PathWhiz Pathway Leucine Stimulation on Insulin Signaling
Reactome mTORC1-mediated signalling
WikiPathways ErbB Signaling Pathway
Interferon type I signaling pathways
G13 Signaling Pathway
IL-2 Signaling Pathway
Insulin Signaling
Cytoplasmic Ribosomal Proteins
EGF/EGFR Signaling Pathway
IL-4 Signaling Pathway
IL-6 signaling pathway
Kit receptor signaling pathway
Apoptosis-related network due to altered Notch3 in ovarian cancer
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
BDNF signaling pathway
Interleukin-11 Signaling Pathway
FSH signaling pathway
Leptin signaling pathway
TSH signaling pathway
Signaling by Insulin receptor
TOR Signaling
AMPK Signaling
IL-5 Signaling Pathway
References
Ref 531100Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem J. 2010 Oct 15;431(2):245-55.
Ref 531100Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem J. 2010 Oct 15;431(2):245-55.

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