Drug Information
Drug General Information | |||||
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Drug ID |
D0Y4AZ
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Former ID |
DIB011637
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Drug Name |
GALOCITABINE
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Synonyms |
Galocitabine < Rec INN >; Ro-09-1390; N-[1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydro-4-pyrimidinyl]-3,4,5-trimethoxybenzamide; 5'-Deoxy-5-fluoro-N4-(3,4,5-trimethoxybenzoyl)cytidine
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Drug Type |
Small molecular drug
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Indication | Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] | Discontinued in Phase 3 | [545231] | ||
Structure |
Download2D MOL |
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Formula |
C19H22FN3O8
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Canonical SMILES |
COc1cc(cc(OC)c1OC)C(=O)NC2=NC(=O)N(C=C2F)[C@@H]3O[C@H](<br />C)[C@@H](O)[C@H]3O
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InChI |
1S/C19H22FN3O8/c1-8-13(24)14(25)18(31-8)23-7-10(20)16(22-19(23)27)21-17(26)9-5-11(28-2)15(30-4)12(6-9)29-3/h5-8,13-14,18,24-25H,1-4H3,(H,21,22,26,27)/t8-,13-,14-,18-/m1/s1
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InChIKey |
TVYPSLDUBVTDIS-FUOMVGGVSA-N
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CAS Number |
CAS 124012-42-6
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Thymidylate synthase | Target Info | Inhibitor | [534250] | |
BioCyc Pathway | Pyrimidine deoxyribonucleotides biosynthesis from CTP | ||||
Pyrimidine deoxyribonucleotides de novo biosynthesis | |||||
Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis | |||||
Superpathway of pyrimidine deoxyribonucleoside salvage | |||||
DTMP de novo biosynthesis (mitochondrial) | |||||
Pyrimidine deoxyribonucleosides salvage | |||||
Pathway Interaction Database | E2F transcription factor network | ||||
PathWhiz Pathway | Pyrimidine Metabolism | ||||
WikiPathways | Trans-sulfuration and one carbon metabolism | ||||
Retinoblastoma (RB) in Cancer | |||||
One Carbon Metabolism | |||||
Integrated Pancreatic Cancer Pathway | |||||
miR-targeted genes in muscle cell - TarBase | |||||
miR-targeted genes in lymphocytes - TarBase | |||||
miR-targeted genes in leukocytes - TarBase | |||||
miR-targeted genes in epithelium - TarBase | |||||
Metabolism of nucleotides | |||||
Fluoropyrimidine Activity | |||||
References |
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