Drug Information

Drug General Information
Drug ID
D0Y3JF
Former ID
DIB018522
Drug Name
2,2,2-TEMPS
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541475]
Formula
C19H23F3N2O3S
InChI
InChI=1S/C19H23F3N2O3S/c1-3-6-15(2)27-18-9-4-8-17(11-18)24(13-16-7-5-10-23-12-16)28(25,26)14-19(20,21)22/h4-5,7-12,15H,3,6,13-14H2,1-2H3
InChIKey
ICFXZBZASBXILF-UHFFFAOYSA-N
PubChem Compound ID
11362035
PubChem Substance ID
16454485, 23518961, 42441295, 77199355, 103323504, 104035682, 178102946, 178102947, 232428810
Target and Pathway
Target(s) Metabotropic glutamate receptor 2 Target Info Modulator (allosteric modulator) [527079]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 541475(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6329).
Ref 527079SAR study of a subtype selective allosteric potentiator of metabotropic glutamate 2 receptor, N-(4-phenoxyphenyl)-N-(3-pyridinylmethyl)ethanesulfonamide. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3099-102.

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