Drug Information

Drug General Information
Drug ID
D0Y2LR
Former ID
DAP000859
Drug Name
Doxylamine
Synonyms
Dossilamina; Doxilamina; Doxilminio; Doxylaminum; Dossilamina [DCIT]; Diclectin (TN); Dolased (TN); Donormyl (TN); Dormidina (TN); Doxilminio [INN-Spanish]; Doxylamine (INN); Doxylamine [INN:BAN]; Doxylaminum [INN-Latin]; Dozile (TN); Evanorm (TN); Mersyndol (TN); Restavit (TN); Somnil (TN); Syndol (TN); Unisom-2 (TN); Phenyl-2-pyridylmethyl-beta-N,N-dimethylaminoethyl ether; N,N-Dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)ethanamine; N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine; N,N-dimethyl-2-[(1-phenyl-1-pyridin-2-ylethyl)oxy]ethanamine; N,N-dimethyl-2-[1-phenyl-1-(pyridin-2-yl)ethoxy]ethanamine; 2-(alpha-(2-(Dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine; 2-Dimethylaminoethoxyphenylmethyl-2-picoline
Drug Type
Small molecular drug
Indication Anxiety disorder; Morning sickness [ICD9: 300, 643.0; ICD10:F40-F42, O21.0] Approved [538170], [542181]
Therapeutic Class
Hypnotics and Sedatives
Company
Ion Healthcare
Structure
Download
2D MOL

3D MOL
Formula
C17H22N2O
InChI
InChI=1S/C17H22N2O/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16/h4-12H,13-14H2,1-3H3
InChIKey
HCFDWZZGGLSKEP-UHFFFAOYSA-N
CAS Number
CAS 469-21-6
PubChem Compound ID
3162
PubChem Substance ID
4407403, 7979131, 8152014, 10523560, 11336016, 11361255, 11363908, 11366470, 11369032, 11371258, 11374274, 11377194, 11462227, 11466055, 11467175, 11483866, 11485750, 11487931, 11490225, 11492343, 11494828, 14872648, 29222304, 46506354, 47736532, 47736533, 47810800, 47885461, 47959795, 48035178, 48185042, 48334546, 48415929, 49698860, 49854351, 50105257, 50105258, 50105259, 52078799, 53787513, 56464430, 85209768, 85788879, 90340822, 92714613, 96024574, 99281835, 103266950, 104302705, 124749641
ChEBI ID
ChEBI:51380
SuperDrug ATC ID
R06AA09
SuperDrug CAS ID
cas=000469216
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [536000], [536430]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538170FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040167.
Ref 542181(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7171).
Ref 536000Steady-state brain concentrations of antihistamines in rats: interplay of membrane permeability, P-glycoprotein efflux and plasma protein binding. Pharmacology. 2004 Oct;72(2):92-8.
Ref 536430First-generation H1 antihistamines found in pilot fatalities of civil aviation accidents, 1990-2005. Aviat Space Environ Med. 2007 May;78(5):514-22.

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