| Drug General Information |
| Drug ID |
D0Y2JI
|
| Former ID |
DIB021240
|
| Drug Name |
xylazine
|
| Synonyms |
Bayer 1470; Narcoxyl; Rompun; Xylapan; Xylasol; Xylzin; BAY-VA-1470
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C12H16N2S
|
| InChI |
InChI=1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14)
|
| InChIKey |
BPICBUSOMSTKRF-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
3712514, 6134291, 6383461, 8149776, 8153496, 10321871, 11111970, 11111971, 11335624, 11360863, 11364161, 11366723, 11369285, 11372622, 11374076, 11377447, 11461835, 11466626, 11467746, 11485051, 11486431, 11489264, 11491287, 11492054, 11495081, 14797946, 24902128, 26612232, 26679606, 26747186, 26747187, 26752277, 29224744, 47216724, 47291083, 47440194, 47440195, 47440196, 47588946, 47588947, 47662224, 47959679, 48334433, 49698575, 50051422, 50085432, 50105055, 50532260, 53837769, 57322904
|
| Target and Pathway |
| Target(s) |
Alpha-2B adrenergic receptor |
Target Info |
Agonist |
[2]
|
|---|
| Alpha-2C adrenergic receptor |
Target Info |
Agonist |
[2]
|
|
KEGG Pathway
|
cGMP-PKG signaling pathway
|
|
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
PANTHER Pathway
|
Alpha adrenergic receptor signaling pathway
|
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
|
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Reactome
|
Adrenoceptors
|
|
Adrenaline signalling through Alpha-2 adrenergic receptor
|
|
G alpha (i) signalling events
|
|
G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
|
|
Adrenaline,noradrenaline inhibits insulin secretion
|
|
G alpha (z) signalling events
|
|
Surfactant metabolism
|
|
WikiPathways
|
Monoamine GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
|
Platelet Aggregation (Plug Formation)
|
|
GPCR ligand binding
|
|
GPCR downstream signalingWP58:Monoamine GPCRs
|
|
Integration of energy metabolism
|
|
GPCR downstream signaling
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 523). |
|---|
| REF 2 | Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S]GTPgammaS binding. Biochem Pharmacol. 1998 Apr 1;55(7):1035-43. |
|---|
