Drug Information
Drug General Information | |||||
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Drug ID |
D0Y2HR
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Former ID |
DAP000326
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Drug Name |
Astemizole
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Synonyms |
Alermizol; Astemina; Astemisan; Astemisol; Astemison; Astemizol; Astemizolum; Astesen; Emdar; Esmacen;Fustermizol; Hestazol; Hismanal; Histamen; Histaminos; Histazol; Hubermizol; Kelp; Laridal; Metodih; Metodik; Paralergin; Retolen; Rifedot; Rimbol; Romadin; Simprox; Urdrim; Wareezol; Waruzol; AlacanBrand of Astemizole; Alonga Brand of Astemizole; Astemizol Alonga; Astemizol [German]; Astemizol ratiopharm; Astemizole Alacan Brand; Astemizole Alonga Brand; Astemizole Byk Brand; Astemizole Diba Brand; Astemizole Elfar Brand; Astemizole Esteve Brand; Astemizole Fustery Brand; Astemizole ICN Brand; Astemizole Janssen Brand; Astemizole Lesvi Brand; Astemizole McNeil Brand; Astemizole Medinsa Brand; Astemizole Merck Brand; Astemizole Senosiain Brand; Astemizole Septa Brand; Astemizole Smaller Brand; Astemizole Urbion Brand; Astemizole Vita Brand; Astemizole ratiopharm Brand; Byk Brand of Astemizole; Diba Brand of Astemizole; Elfar Brand of Astemizole; Esteve Brand of Astemizole; Fustery Brand of Astemizole; ICN Brand of Astemizole; Janssen Brand of Astemizole; Lesvi Brand of Astemizole; McNeil Brand of Astemizole; Medinsa Brand of Astemizole; Merck Brand of Astemizole; Ratiopharm Brand of Astemizole; Reig Jofre Brand of Astemizole; Senosiain Brand of Astemizole; Septa Brand of Astemizole; Smaller Brand of Astemizole; Urbion Brand of Astemizole; Vita Brand of Astemizole; R 42512; R 43 512; R43512; [3H]Astemizole; Alonga, Astemizol; Astemizol [INN-Spanish]; Astemizolum [INN-Latin]; HISMANAL (TN); Hismanal (TN); MJD-30; Nono-Nastizol A; Novo-mastizol A; R-43512; Ratiopharm, Astemizol; Astemizole [USAN:BAN:INN]; GNF-PF-2461; R-43-512; Astemizole (JAN/USP/INN); Hestazol, Kelp, Laridal, Retolen, Wareezol, HSBD 6799, BRN 4830190; 1-(p-Fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazole
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Drug Type |
Small molecular drug
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Therapeutic Class |
Antiallergic Agents
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Company |
Janssen Pharmaceutica
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Structure |
Download2D MOL |
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Formula |
C28H31FN4O
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InChI |
InChI=1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31)
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InChIKey |
GXDALQBWZGODGZ-UHFFFAOYSA-N
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CAS Number |
CAS 68844-77-9
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PubChem Compound ID | |||||
PubChem Substance ID |
9050, 459037, 855746, 4266413, 5313663, 7847301, 7978732, 8150150, 8151518, 10321136, 11112828, 11335214, 11360453, 11363342, 11365904, 11368466, 11372003, 11374824, 11376628, 11461425, 11466164, 11467284, 11485540, 11485887, 11489548, 11490887, 11493037, 11494262, 11528621, 11538010, 12013338, 14760289, 22391432, 26613163, 26680817, 26746979, 26746980, 26751496, 26751497, 29221421, 46487928, 46508569, 47216611, 47440072, 47515146, 47736292, 47810587, 47885241, 48034934, 48259050
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SuperDrug ATC ID |
R06AX11
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SuperDrug CAS ID |
cas=068844779
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Target and Pathway | |||||
Target(s) | Histamine H1 receptor | Target Info | Antagonist | [537070], [537328] | |
PANTHER Pathway | Histamine H1 receptor mediated signaling pathway | ||||
References | |||||
Ref 534869 | Comparative tolerability of second generation antihistamines. Drug Saf. 1999 May;20(5):385-401. | ||||
Ref 539680 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2603). | ||||
Ref 537070 | Histamine and the convulsive threshold or effectiveness of antiepileptic drugs. Przegl Lek. 2008;65(11):803-6. | ||||
Ref 537328 | Histamine H1 receptor induces cytosolic calcium increase and aquaporin translocation in human salivary gland cells. J Pharmacol Exp Ther. 2009 Aug;330(2):403-12. Epub 2009 May 14. |
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