Drug Information

Drug General Information
Drug ID
D0Y1IF
Former ID
DNC005394
Drug Name
FR-193262
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527580]
Structure
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2D MOL

3D MOL
Formula
C31H29N2NaO4
Canonical SMILES
C1CC(C2=C(C1)C(=CC=C2)OCC(=O)[O-])N3CCCC3C4=NC(=C(O4)C5<br />=CC=CC=C5)C6=CC=CC=C6.[Na+]
InChI
1S/C31H30N2O4.Na/c34-28(35)20-36-27-18-8-14-23-24(27)15-7-16-25(23)33-19-9-17-26(33)31-32-29(21-10-3-1-4-11-21)30(37-31)22-12-5-2-6-13-22;/h1-6,8,10-14,18,25-26H,7,9,15-17,19-20H2,(H,34,35);/q;+1/p-1/t25-,26-;/m1./s1
InChIKey
NRXVVCOCESTRSY-JUJAXGASSA-M
PubChem Compound ID
23664784
Target and Pathway
Target(s) Prostacyclin receptor Target Info Inhibitor [527580]
KEGG Pathway Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Platelet activation
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
Endothelin Pathways
Platelet homeostasis
GPCR ligand binding
GPCR downstream signaling
References
Ref 527580Bioorg Med Chem Lett. 2005 Jul 1;15(13):3279-83.Discovery of new diphenyloxazole derivatives containing a pyrrolidine ring: orally active prostacyclin mimetics. Part 2.
Ref 527580Bioorg Med Chem Lett. 2005 Jul 1;15(13):3279-83.Discovery of new diphenyloxazole derivatives containing a pyrrolidine ring: orally active prostacyclin mimetics. Part 2.

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