Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0Y0JH
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| Former ID |
DAP000734
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| Drug Name |
Salsalate
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| Synonyms |
Diacesal; Diplosal; Disalcid; Disalicylsaeure; Disalyl; Nobacid; Salflex; Salical; Salina; Saloxium; Salsalato; Salsalatum;Salysal; Sasapirin; Sasapyrin; Sasapyrine; Sasapyrinum; Disalicylic acid; Sal Ester Sal; Salicylic Acid Salicylate; Salicyloylsalicylic acid; Salicylsalicylic acid; Disalcid (TN); O-Salicylcylsalicylsaeure; O-Salicyloylsalicylic Acid; O-Salicylsalicylic acid; Salflex (TN); Salicylic acid, bimolecular ester; Salicylic acid, salicylate; Salsalato [INN-Spanish]; Salsalatum [INN-Latin]; Salsitab (TN); Sasapyrine (JAN); Mono-Gesic (TN); Salsalate (USP/INN); Salsalate [USAN:INN:BAN]; Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester; 2-((2-Hydroxybenzoyl)oxy)benzoic acid; 2-(2-hydroxybenzoyl)oxybenzoic acid; 2-Carboxyphenyl salicylate; 2-Salicyloyloxybenzoic Acid; 2-{[(2-hydroxyphenyl)carbonyl]oxy}benzoic acid
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| Drug Type |
Small molecular drug
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| Indication | Rheumatold arthritis; Osteoarthritis [ICD9: 714, 715; ICD10:M05-M06, M15-M19, M47] | Approved | [1], [2] | ||
| Therapeutic Class |
Antiinflammatory Agents
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| Structure |
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Download2D MOL |
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| Formula |
C14H10O5
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| Canonical SMILES |
C1=CC=C(C(=C1)C(=O)OC2=CC=CC=C2C(=O)O)O
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| InChI |
1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17)
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| InChIKey |
WVYADZUPLLSGPU-UHFFFAOYSA-N
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| CAS Number |
CAS 552-94-3
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| PubChem Compound ID | |||||
| PubChem Substance ID |
101463, 220693, 3134440, 5591035, 7847494, 8153173, 10526880, 11364971, 11367533, 11370095, 11371265, 11374638, 11378266, 11484581, 11488509, 11489989, 11492755, 11495812, 14798887, 26613017, 26679829, 26683807, 26750031, 29224223, 46506882, 47216943, 47885574, 48416531, 49887489, 50107792, 57322633, 76311971, 87575737, 92307195, 92716557, 103401161, 103848157, 104308445, 107915682, 117574614, 118266874, 124585059, 124637486, 125353002, 126622839, 126654325, 126677823, 129642109, 134222723, 134338021
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| SuperDrug ATC ID |
N02BA06
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| SuperDrug CAS ID |
cas=000552943
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| Target and Pathway | |||||
| Target(s) | Prostaglandin G/H synthase 1 | Target Info | Inhibitor | [3], [4] | |
| BioCyc Pathway | C20 prostanoid biosynthesis | ||||
| KEGG Pathway | Arachidonic acid metabolism | ||||
| Metabolic pathways | |||||
| Platelet activation | |||||
| Serotonergic synapse | |||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| PANTHER Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | ||||
| PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
| WikiPathways | Prostaglandin Synthesis and Regulation | ||||
| Arachidonic acid metabolism | |||||
| Phase 1 - Functionalization of compounds | |||||
| Eicosanoid Synthesis | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
| REF 1 | Drug information of Salsalate, 2008. eduDrugs. | ||||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
| REF 3 | Aspirin and NSAID sensitivity. Immunol Allergy Clin North Am. 2004 Aug;24(3):491-505, vii. | ||||
| REF 4 | New non-steroidal anti-rheumatic drugs: selective inhibitors of inducible cyclooxygenase. Med Klin (Munich). 1998 Jul 15;93(7):407-15. | ||||
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