Drug Information

Drug General Information
Drug ID
D0XY3G
Former ID
DIB018516
Drug Name
2-(2-thiazolyl)ethanamine
Synonyms
2-thiazoleethanamine; 2-thiazolylethylamine; 2-(2-aminoethyl)thiazole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538704]
Structure
Download
2D MOL
Formula
C5H8N2S
InChI
InChI=1S/C5H8N2S/c6-2-1-5-7-3-4-8-5/h3-4H,1-2,6H2
InChIKey
TWZOYAWHWDRMEZ-UHFFFAOYSA-N
PubChem Compound ID
87653
PubChem Substance ID
10222545, 15066180, 44418910, 47510099, 47731286, 49846680, 50064558, 57334365, 57565808, 77903683, 85208916, 91097527, 92729673, 96024148, 103122444, 103193827, 104394464, 104812445, 117522156, 117531396, 117677572, 118078219, 121279972, 125292686, 125327175, 125410594, 129326154, 129652146, 131383609, 135042351, 135606373, 135649682, 142507455, 143424665, 143896361, 162055648, 162209071, 162474504, 163585536, 163796673, 164772042, 166984611, 170520697, 186015956, 202822041, 223393723, 223446362, 223569500, 224780340, 226957200
Target and Pathway
Target(s) Histamine H1 receptor Target Info Agonist [526569]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538704(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1193).
Ref 526569Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor. J Pharmacol Exp Ther. 2003 Jun;305(3):1104-15. Epub 2003 Mar 6.

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