Drug Information

Drug General Information
Drug ID
D0XW9L
Former ID
DNC001212
Drug Name
Rifalazil
Drug Type
Small molecular drug
Indication Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10:A00-B99] Phase 3 [521757]
Structure
Download
2D MOL

3D MOL
Formula
C51H64N4O13
Canonical SMILES
CC1C=CC=C(C(=O)N=C2C3=C(C4=C5C(=C(C(=C4C2=O)O)C)OC(C5=O<br />)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)NC6=C(O3)C=C<br />(C=C6O)N7CCN(CC7)CC(C)C)C
InChI
1S/C51H64N4O13/c1-24(2)23-54-16-18-55(19-17-54)32-21-33(57)39-35(22-32)67-48-40(52-39)36-37-44(60)30(8)47-38(36)49(62)51(10,68-47)65-20-15-34(64-11)27(5)46(66-31(9)56)29(7)43(59)28(6)42(58)25(3)13-12-14-26(4)50(63)53-41(48)45(37)61/h12-15,20-22,24-25,27-29,34,42-43,46,52,57-60H,16-19,23H2,1-11H3/b13-12+,20-15+,26-14-,53-41?/t25-,27+,28+,29+,34-,42-,43+,46+,51-/m0/s1
InChIKey
SGHWBDUXKUSFOP-KYALZUAASA-N
CAS Number
CAS 129791-92-0
PubChem Compound ID
6540558
PubChem Substance ID
603306, 604615, 637010, 3727008, 14914349, 14938811, 17396721, 32961412, 50064322, 57370935, 103536525, 126682304, 134340429, 135270008, 142521911, 198973936, 226455621, 252356475
Target and Pathway
Target(s) bacterial RNA polymerase switch region Target Info Inhibitor [536472]
References
Ref 521757ClinicalTrials.gov (NCT00251849) PROVIDENCE-1: Study of Rifalazil in Chlamydia Pneumoniae Seropositive Patients. U.S. National Institutes of Health.
Ref 536472Novel agents in the management of Mycobacterium tuberculosis disease. Curr Med Chem. 2007;14(18):2000-8.

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