Drug General Information
Drug ID	D0XK7G
Former ID	DNC010716
Drug Name	N-hydroxy-2-(4-methoxyphenylsulfonamido)acetamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530746]
Structure		Download 2D MOL 3D MOL
Formula	C9H12N2O5S
Canonical SMILES	COC1=CC=C(C=C1)S(=O)(=O)NCC(=O)NO
InChI	1S/C9H12N2O5S/c1-16-7-2-4-8(5-3-7)17(14,15)10-6-9(12)11-13/h2-5,10,13H,6H2,1H3,(H,11,12)
InChIKey	WLZISXXOYYGJNT-UHFFFAOYSA-N
PubChem Compound ID	10445302
Target and Pathway
Target(s)	Matrix metalloproteinase-14	Target Info	Inhibitor	[530746]
	ADAM 17	Target Info	Inhibitor	[530746]
KEGG Pathway	TNF signaling pathway
	GnRH signaling pathwayhsa04330:Notch signaling pathway
	Alzheimer's disease
	Epithelial cell signaling in Helicobacter pylori infection
PANTHER Pathway	Alzheimer disease-presenilin pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Alzheimer disease-presenilin pathway
	Notch signaling pathway
Pathway Interaction Database	HIF-2-alpha transcription factor network
	Signaling events mediated by focal adhesion kinaseerbb4_pathway:ErbB4 signaling events
	TNF receptor signaling pathway
	p75(NTR)-mediated signaling
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix MetalloproteinasesR-HSA-1251985:Nuclear signaling by ERBB4
	Regulated proteolysis of p75NTR
	Activated NOTCH1 Transmits Signal to the Nucleus
	Constitutive Signaling by NOTCH1 PEST Domain Mutants
	Constitutive Signaling by NOTCH1 t(7
	M1580_K2555) Translocation Mutant
	Constitutive Signaling by NOTCH1 HD Domain Mutants
	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	TNF signaling
	Growth hormone receptor signaling
WikiPathways	Senescence and Autophagy in Cancer
	Activation of Matrix Metalloproteinases
	Degradation of collagen
	AGE/RAGE pathway
	Matrix MetalloproteinasesWP61:Notch Signaling Pathway
	Copper homeostasis
	Notch Signaling Pathway
	Growth hormone receptor signaling
	BDNF signaling pathway
	Alzheimers Disease
	Signalling by NGF
	Extrinsic Pathway for Apoptosis
References
Ref 530746	J Med Chem. 2010 Mar 25;53(6):2622-35.Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models.
Ref 530746	J Med Chem. 2010 Mar 25;53(6):2622-35.Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models.

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