Drug Information

Drug General Information
Drug ID
D0XD4M
Former ID
DIB018250
Drug Name
[3H]BWA868C
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539198]
Structure
Download
2D MOL
Formula
C25H37N3O5
InChI
InChI=1S/C25H37N3O5/c29-22(20-13-7-4-8-14-20)17-26-28-21(15-9-1-2-10-16-23(30)31)24(32)27(25(28)33)18-19-11-5-3-6-12-19/h3,5-6,11-12,20-22,26,29H,1-2,4,7-10,13-18H2,(H,30,31)
InChIKey
YZJVWSKJHGEIBL-UHFFFAOYSA-N
PubChem Compound ID
122021
PubChem Substance ID
7978836, 10239906, 14931487, 29302491, 47285791, 47731162, 48253856, 48253857, 49980272, 53462466, 53788413, 57339908, 85208992, 104414838, 125334179, 135076719, 135650043, 135651140, 143155830, 162250187, 162312826, 163304442, 172918743, 179293737, 201505491, 204378140, 226933504, 252320721, 252457399
Target and Pathway
Target(s) Prostaglandin D2 receptor Target Info Antagonist [525913]
KEGG Pathway Neuroactive ligand-receptor interaction
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539198(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1899).
Ref 525913Pharmacology and autoradiography of human DP prostanoid receptors using [(3)H]-BWA868C, a DP receptor-selective antagonist radioligand. Br J Pharmacol. 2000 Nov;131(6):1025-38.

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