Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0X8QI
|
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| Former ID |
DIB006689
|
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| Drug Name |
UP-116-77
|
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| Synonyms |
Mipitroban
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| Drug Type |
Small molecular drug
|
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| Indication | Thromboembolism [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] | Terminated | [1] | ||
| Company |
Laboratories UPSA
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C19H19Cl2N3O2
|
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| Canonical SMILES |
n1(c(nc2c1ncc(c2)Cl)CC(C(=O)O)(C)C)Cc1ccc(Cl)cc1
|
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| CAS Number |
CAS 136122-46-8
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Thromboxane A2 receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Platelet activation | |||||
| Reactome | Prostanoid ligand receptors | ||||
| G alpha (q) signalling events | |||||
| G alpha (12/13) signalling events | |||||
| Thromboxane signalling through TP receptor | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Small Ligand GPCRs | |||||
| Signal amplification | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005083) | ||||
| REF 2 | Synthesis and structure-activity relationships of novel benzimidazole and imidazo[4,5-b]pyridine acid derivatives as thromboxane A2 receptor antagonists. J Med Chem. 1993 Apr 30;36(9):1175-87. | ||||
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