Drug General Information
Drug ID
D0X8BU
Former ID
DIB019337
Drug Name
compound 20
Synonyms
PCM126
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532265]
Structure
Download
2D MOL
Formula
C35H50N2O4
InChI
InChI=1S/C35H50N2O4/c1-21(8-13-32(39)37-31(33(40)41)18-22-20-36-30-7-5-4-6-25(22)30)27-11-12-28-26-10-9-23-19-24(38)14-16-34(23,2)29(26)15-17-35(27,28)3/h4-7,20-21,23-24,26-29,31,36,38H,8-19H2,1-3H3,(H,37,39)(H,40,41)/t21-,23-,24-,26+,27-,28+,29+,31+,34+,35-/m1/s1
InChIKey
ITOFPJRDSCGOSA-KZLRUDJFSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Ephrin type-A receptor 2 Target Info Inhibitor [532265]
EPH receptor B6 Target Info Inhibitor [532265]
EPH receptor A8 Target Info Inhibitor [532265]
EPH receptor A1 Target Info Inhibitor [532265]
EPH receptor A6 Target Info Inhibitor [532265]
EPH receptor A5 Target Info Inhibitor [532265]
Ephrin type-B receptor 4 Target Info Inhibitor [532265]
Epha3 tyrosine kinase receptor Target Info Inhibitor [532265]
Epha4 tyrosine kinase receptor Target Info Inhibitor [532265]
EPH receptor B3 Target Info Inhibitor [532265]
EPH receptor A7 Target Info Inhibitor [532265]
EPH receptor B1 Target Info Inhibitor [532265]
Ephrin type-B receptor 2 Target Info Inhibitor [532265]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
PI3K-Akt signaling pathway
Axon guidancehsa04360:Axon guidancehsa04360:Axon guidancehsa04360:Axon guidancehsa04360:Axon guidance
NetPath Pathway TGF_beta_Receptor Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Angiogenesis
Pathway Interaction Database EphrinA-EPHA pathway
Arf6 signaling events
Direct p53 effectors
EPHA forward signaling
Stabilization and expansion of the E-cadherin adherens junction
EPHA2 forward signalingephbfwdpathway:EPHB forward signaling
EphrinB-EPHB pathway
Ephrin B reverse signalingephrina_ephapathway:EphrinA-EPHA pathway
EPHA forward signalingephrina_ephapathway:EphrinA-EPHA pathway
EPHA forward signalingephbfwdpathway:EPHB forward signaling
Syndecan-2-mediated signaling events
Ephrin B reverse signaling
Reactome EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cellsR-HSA-2682334:EPH-Ephrin signaling
EPHB-mediated forward signaling
L1CAM interactions
EPH-ephrin mediated repulsion of cells
WikiPathways NRF2 pathwayWP2877:Vitamin D Receptor PathwayWP2884:NRF2 pathwayWP2854:Gene regulatory network modelling somitogenesis
Spinal Cord InjuryWP3:Transcriptional activation by NRF2
NLR Proteins
Regulation of Microtubule Cytoskeleton
L1CAM interactions
References
Ref 532265Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem. 2013 Apr 11;56(7):2936-47.
Ref 532265Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem. 2013 Apr 11;56(7):2936-47.

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