TTD | Drug: D0X6PY

Drug General Information
Drug ID	D0X6PY
Former ID	DIB019818
Drug Name	EP 157
Synonyms	EP-157; EP157
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541162]
Structure		Download 2D MOL 3D MOL
Formula	C29H33NO3
InChI	InChI=1S/C29H33NO3/c31-28(32)16-10-2-1-9-15-26-22-17-19-23(20-18-22)27(26)21-30-33-29(24-11-5-3-6-12-24)25-13-7-4-8-14-25/h1,3-9,11-14,17,19,21-23,26-27,29H,2,10,15-16,18,20H2,(H,31,32)/b9-1-,30-21+/t22-,23+,26+,27+/m0/s1
InChIKey	NBBRUBRIVJNCKV-BYSZDLRWSA-N
PubChem Compound ID	73755162
Target and Pathway
Target(s)	Prostacyclin receptor	Target Info	Agonist	[533410]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
	Platelet activation
Pathway Interaction Database	Thromboxane A2 receptor signaling
PathWhiz Pathway	Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
Reactome	Prostanoid ligand receptors
Reactome	G alpha (s) signalling events
WikiPathways	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	Endothelin Pathways
	Platelet homeostasis
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 541162	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5853).
Ref 533410	Prostaglandin endoperoxide analogues which are both thromboxane receptor antagonists and prostacyclin mimetics. Br J Pharmacol. 1986 Mar;87(3):543-51.

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Drug Information