TTD | Drug: D0X6DO

Drug General Information
Drug ID	D0X6DO
Former ID	DIB020183
Drug Name	L-826266
Synonyms	MF266-3; LS-193774; compound 10b [PMID: 11504634]
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[526121]
Structure		Download 2D MOL
Formula	C27H21BrClNO4S
InChI	InChI=1S/C27H21BrClNO4S/c1-34-25-12-10-23(28)17-26(25)35(32,33)30-27(31)13-9-22-16-24(29)11-8-21(22)15-18-6-7-19-4-2-3-5-20(19)14-18/h2-14,16-17H,15H2,1H3,(H,30,31)/b13-9+
InChIKey	DYXFUJYHEDGCLS-UKTHLTGXSA-N
PubChem Compound ID	9808643
PubChem Substance ID	44844634, 50077005, 53789004, 56239271, 57273838, 78681325, 135305033, 142468575, 178102469, 227309875, 227309879
Target and Pathway
Target(s)	Prostaglandin E2 receptor EP3 subtype	Target Info	Antagonist	[531234]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Regulation of lipolysis in adipocytes
	Pathways in cancer
NetPath Pathway	IL2 Signaling Pathway
Reactome	Prostanoid ligand receptors
Reactome	G alpha (i) signalling events
WikiPathways	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 526121	Structure-activity relationship of cinnamic acylsulfonamide analogues on the human EP3 prostanoid receptor. Bioorg Med Chem. 2001 Aug;9(8):1977-84.
Ref 531234	Roles of affinity and lipophilicity in the slow kinetics of prostanoid receptor antagonists on isolated smooth muscle preparations. Br J Pharmacol. 2011 Feb;162(4):863-79.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.

Drug Information