Drug Information

Drug General Information
Drug ID
D0X3MK
Former ID
DIB019794
Drug Name
DZNep
Synonyms
3-deazaneplanocin A
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533455]
Structure
Download
2D MOL
Formula
C12H14N4O3
InChI
InChI=1S/C12H16N4O3/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19/h1-2,5-6,8,10-11,17-19H,3-4H2,(H2,13,14)/t6?,8?,10-,11+/m1/s1
InChIKey
XNJHAZWZQGXOSC-FDNQDJDWSA-N
PubChem Compound ID
73087
PubChem Substance ID
615106, 8195549, 15221583, 24717549, 43129111, 75061254, 92098549, 103064415, 103078364, 103405348, 104354458, 109693483, 117524162, 118047210, 126683146, 135030528, 137263204, 138769807, 152258216, 152344544, 160647052, 162768946, 184607915, 186014818, 204400609, 223653078, 227133899, 237369420, 249492591, 252214387, 252392863, 252428751, 252476359
Target and Pathway
Target(s) Adenosylhomocysteinase Target Info Inhibitor [533455]
BioCyc Pathway Superpathway of methionine degradation
Methionine degradation
Cysteine biosynthesis
KEGG Pathway Cysteine and methionine metabolism
Metabolic pathways
PathWhiz Pathway Selenoamino Acid Metabolism
Betaine Metabolism
Methionine Metabolism
WikiPathways Metabolism of amino acids and derivatives
Trans-sulfuration and one carbon metabolism
One Carbon Metabolism
Trans-sulfuration pathway
Phase II conjugation
Folate Metabolism
References
Ref 5334553-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60. Biochem Biophys Res Commun. 1986 Mar 13;135(2):688-94.
Ref 5334553-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60. Biochem Biophys Res Commun. 1986 Mar 13;135(2):688-94.

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