Drug Information
Drug General Information | |||||
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Drug ID |
D0X2TO
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Former ID |
DCL000680
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Drug Name |
Adatanserin
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Synonyms |
Adatanserin [INN]; WY 50324; N-[2-(4-pyrimidin-2-ylpiperazin-1-yl)ethyl]adamantane-1-carboxamide
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Drug Type |
Small molecular drug
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Indication | Severe mood disorders [ICD9: 296; ICD10:F30-F39] | Discontinued in Phase 2 | [536580] | ||
Company |
Wyeth
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Structure |
Download2D MOL |
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Formula |
C21H31N5O
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Canonical SMILES |
C1CN(CCN1CCNC(=O)C23CC4CC(C2)CC(C4)C3)C5=NC=CC=N5
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InChI |
1S/C21H31N5O/c27-19(21-13-16-10-17(14-21)12-18(11-16)15-21)22-4-5-25-6-8-26(9-7-25)20-23-2-1-3-24-20/h1-3,16-18H,4-15H2,(H,22,27)
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InChIKey |
HPFLVTSWRFCPCV-UHFFFAOYSA-N
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CAS Number |
CAS 127266-56-2
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | 5-hydroxytryptamine 1A receptor | Target Info | Agonist | [534942], [536580] | |
5-hydroxytryptamine 2A receptor | Target Info | Antagonist | [534942], [536580] | ||
WikiPathways | Serotonin HTR1 Group and FOS Pathway | ||||
SIDS Susceptibility Pathways | |||||
Monoamine GPCRs | |||||
GPCRs, Class A Rhodopsin-like | |||||
GPCR ligand binding | |||||
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling | |||||
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
GPCR downstream signaling | |||||
GPCRs, Other | |||||
References | |||||
Ref 534942 | Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents. J Med Chem. 1999Dec 16;42(25):5077-94. | ||||
Ref 536580 | Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2. |
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