Drug General Information
Drug ID
D0X0WU
Former ID
DIB011114
Drug Name
Tolperisone
Synonyms
Agileo; Viveo; AV-650; SPH-3047; Tolperisone (controlled-release); Tolperisone (controlled-release), Sanochemia; Tolperisone (controlled-release), Sanochemia/Avigen
Drug Type
Small molecular drug
Indication Muscle spasm [ICD10:M62.838] Approved [551871]
Company
Sanochemia Pharmazeutika AG
Structure
Download
2D MOL

3D MOL

Formula
C16H24ClNO
Canonical SMILES
C(=O)(C(CN1CCCCC1)C)c1ccc(cc1)C
CAS Number
CAS 728-88-1
PubChem Compound ID
Target and Pathway
Target(s) Voltage-gated sodium channel Target Info Modulator [527704], [551871]
Voltage-dependent calcium channel Target Info Modulator [527704], [530122]
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 527704Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels. J Pharmacol Exp Ther. 2005 Dec;315(3):1237-46. Epub 2005 Aug 26.
Ref 530122Inhibitory effect of glutamate release from rat cerebrocortical synaptosomes by dextromethorphan and its metabolite 3-hydroxymorphinan. Neurochem Int. 2009 Jul;54(8):526-34.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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