Drug General Information
Drug ID	D0W9VN
Former ID	DIB021187
Drug Name	VU0364770
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541403]
Structure		Download 2D MOL
Formula	C12H9ClN2O
InChI	InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)
InChIKey	SUYUTNCKIOLMAJ-UHFFFAOYSA-N
PubChem Compound ID	836002
PubChem Substance ID	1075412, 7068684, 8240697, 45826308, 50781779, 81083915, 85240655, 89676687, 103692716, 104135294, 107567746, 110019984, 119048943, 162009803, 162619066, 163563935, 178102855, 196377575, 228633058, 248986748, 249548948, 252158087, 252472568
Target and Pathway
Target(s)	Metabotropic glutamate receptor 4	Target Info	Modulator (allosteric modulator)	[531700]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Glutamatergic synapse
	Taste transduction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
Reactome	G alpha (i) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	GPCRs, Class C Metabotropic glutamate, pheromone
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 541403	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6234).
Ref 531700	The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease. J Pharmacol Exp Ther. 2012 Feb;340(2):404-21.

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