Drug Information

Drug General Information
Drug ID
D0W9LJ
Former ID
DNC003294
Drug Name
Metiamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538746]
Structure
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2D MOL

3D MOL
Formula
C9H16N4S2
InChI
InChI=1S/C9H16N4S2/c1-7-8(13-6-12-7)5-15-4-3-11-9(14)10-2/h6H,3-5H2,1-2H3,(H,12,13)(H2,10,11,14)
InChIKey
FPBPLBWLMYGIQR-UHFFFAOYSA-N
CAS Number
CAS 34839-70-8
PubChem Compound ID
1548992
PubChem Substance ID
9652, 454502, 6698911, 8653311, 14774170, 16961280, 17398245, 32248923, 47434826, 47954439, 50061391, 50222525, 57409062, 71922618, 85229947, 89651662, 95515649, 99445275, 103173533, 103914964, 109612907, 110525148, 127879114, 131342042, 134221816, 134998461, 135650597, 137156409, 137263792, 152343567, 160969712, 162011533, 163415887, 163620956, 163686278, 163910534, 166729885, 172868618, 174529016, 179293854, 185990418, 198939253, 223440325, 223563202, 224774955, 226845005, 236556847, 242060280, 249962168, 252215738
Target and Pathway
Target(s) Histamine H2 receptor Target Info Antagonist [551376]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway Intracellular Signalling Through Histamine H2 Receptor and Histamine
Gastric Acid Production
Reactome Histamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 538746(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1233).
Ref 551376Metiamide—an orally active histamine H2-receptor antagonist. 1973. Agents Actions. 1994 Dec;43(3-4):91-5; discussion 96.

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