Drug General Information
Drug ID
D0W7VG
Former ID
DCL000423
Drug Name
AMG 108
Drug Type
Small molecular drug
Indication Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Discontinued in Phase 2 [547930]
Company
Amgen
Structure
Download
2D MOL

3D MOL

Formula
C11H14N4O4
Canonical SMILES
C1=C(C2=C(N1)C(=O)N=CN2)C3C(C(C(N3)CO)O)O
InChI
1S/C11H14N4O4/c16-2-5-9(17)10(18)7(15-5)4-1-12-8-6(4)13-3-14-11(8)19/h1,3,5,7,9-10,12,15-18H,2H2,(H,13,14,19)/t5-,7+,9-,10+/m1/s1
InChIKey
IWKXDMQDITUYRK-KUBHLMPHSA-N
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:43362
Target and Pathway
Target(s) Interleukin-1 receptor, type II Target Info Antagonist [536524], [550250]
KEGG Pathway MAPK signaling pathway
Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Amoebiasis
HTLV-I infection
Transcriptional misregulation in cancer
NetPath Pathway IL1 Signaling Pathway
TNFalpha Signaling Pathway
Pathway Interaction Database IL1-mediated signaling events
Reactome Interleukin-1 signaling
WikiPathways MAPK Signaling Pathway
Interleukin-1 signaling
Apoptosis Modulation and Signaling
References
Ref 547930Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020487)
Ref 536524Inflammatory molecules: a target for treatment of systemic autoimmune diseases. Autoimmun Rev. 2007 Nov;7(1):1-7. Epub 2007 Mar 26.
Ref 550250Clinical pipeline report, company report or official report of Amgen (2009).

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