Drug Information

Drug General Information
Drug ID
D0W7UO
Former ID
DCL000083
Drug Name
CGP71683A
Synonyms
CGP-71683A; N-[[4-[[(4-aminoquinazolin-2-yl)amino]methyl]cyclohexyl]methyl]naphthalene-1-sulfonamide
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Discontinued in Phase 3 [538948], [546849]
Company
Servier
Structure
Download
2D MOL

3D MOL
Formula
C26H29N5O2S
InChI
InChI=1S/C26H29N5O2S/c27-25-22-9-3-4-10-23(22)30-26(31-25)28-16-18-12-14-19(15-13-18)17-29-34(32,33)24-11-5-7-20-6-1-2-8-21(20)24/h1-11,18-19,29H,12-17H2,(H3,27,28,30,31)
InChIKey
UULIGRNKXHCLQN-UHFFFAOYSA-N
PubChem Compound ID
5312114
PubChem Substance ID
7978910, 11056881, 24739773, 29215520, 29217718, 39341734, 50416313, 57359513, 85209013, 103181545, 103465696, 103987903, 104052019, 114157903, 124892234, 129422299, 129422300, 131333926, 134338780, 134341415, 135650078, 140179814, 142325330, 163715699, 177748548, 179294236, 198970222, 226663935, 242204482, 248078644, 248094099
Target and Pathway
Target(s) Neuropeptide Y receptor 5 Target Info Antagonist [535122], [536091], [536383]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 538948(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1562).
Ref 546849Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010609)
Ref 535122Neuropeptide Y Y(5) receptor antagonist CGP71683A: the effects on food intake and anxiety-related behavior in the rat. Eur J Pharmacol. 2001 Mar 2;414(2-3):215-24.
Ref 536091Neuropeptide Y induced modulation of dopamine synthesis in the striatum. Regul Pept. 2005 Jul 15;129(1-3):73-8.
Ref 536383Neuropeptide Y-induced enhancement of the evoked release of newly synthesized dopamine in rat striatum: mediation by Y2 receptors. Neuropharmacology. 2007 May;52(6):1396-402. Epub 2007 Feb 20.

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