| Drug General Information |
| Drug ID |
D0W7OE
|
| Former ID |
DAP000954
|
| Drug Name |
Aprindine
|
| Synonyms |
Aprindin; Aprindina; Aprindinum; Aprinidine; Fibocil; AC 1802; Aprindina [INN-Spanish]; Aprindinum [INN-Latin]; Aprindine (USAN/INN); Aprindine [USAN:BAN:INN]; N-(3-(Diethylamino)propyl)-N-phenyl-2-indanamine; N,N-Diethyl-N'-2-indanyl-N'-phenyl-1,3-propanediamine; N,N-Diethyl-N'-2-indanyl-N'-phenyl-1,3-propanediaminemonohydrochloride; N'-(2,3-dihydro-1H-inden-2-yl)-N,N-diethyl-N'-phenylpropane-1,3-diamine; N-(2,3-Dihydro-1H-inden-2-yl)-N',N'-diethyl-N-phenyl-1,3-propanediamine; N-(2,3-dihydro-1H-inden-2-yl)-N',N'-diethyl-N-phenylpropane-1,3-diamine
|
| Drug Type |
Small molecular drug
|
| Indication |
Cardiac arrhythmias [ICD9: 427; ICD10:I47-I49]
|
Approved |
[1]
|
|---|
| Therapeutic Class |
Antiarrhythmic Agents
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C22H30N2
|
| Canonical SMILES |
CCN(CC)CCCN(C1CC2=CC=CC=C2C1)C3=CC=CC=C3
|
| InChI |
1S/C22H30N2/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3
|
| InChIKey |
NZLBHDRPUJLHCE-UHFFFAOYSA-N
|
| CAS Number |
CAS 37640-71-4
|
| PubChem Compound ID |
|
| PubChem Substance ID |
571299, 7548412, 8151505, 10520821, 15494731, 17397126, 29221394, 46505478, 48415575, 50020808, 57321208, 75450772, 90340712, 104239200, 104299952, 134224065, 134338228, 134402261, 134999466, 137006017, 160964697, 179150329, 184530774, 198949331, 226420992, 249950823
|
| SuperDrug ATC ID |
C01BB04
|
| SuperDrug CAS ID |
cas=037640714
|
| Target and Pathway |
| Target(s) |
Calmodulin |
Target Info |
Inhibitor |
[2]
|
|---|
|
KEGG Pathway
|
Ras signaling pathway
|
|
Rap1 signaling pathway
|
|
Calcium signaling pathway
|
|
cGMP-PKG signaling pathway
|
|
cAMP signaling pathway
|
|
Phosphatidylinositol signaling system
|
|
Oocyte meiosis
|
|
Adrenergic signaling in cardiomyocytes
|
|
Vascular smooth muscle contraction
|
|
Circadian entrainment
|
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Long-term potentiation
|
|
Neurotrophin signaling pathway
|
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Dopaminergic synapse
|
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Olfactory transduction
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Phototransduction
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Inflammatory mediator regulation of TRP channels
|
|
Insulin signaling pathway
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GnRH signaling pathway
|
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Estrogen signaling pathway
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Melanogenesis
|
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Oxytocin signaling pathway
|
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Glucagon signaling pathway
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Salivary secretion
|
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Gastric acid secretion
|
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Alzheimer's disease
|
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Amphetamine addiction
|
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Alcoholism
|
|
Pertussis
|
|
Tuberculosis
|
|
Glioma
|
|
NetPath Pathway
|
RANKL Signaling Pathway
|
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TSH Signaling Pathway
|
|
PANTHER Pathway
|
CCKR signaling map ST
|
|
Pathway Interaction Database
|
BCR signaling pathway
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p38 MAPK signaling pathway
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes
|
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
|
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IL2 signaling events mediated by PI3K
|
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IFN-gamma pathway
|
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Lissencephaly gene (LIS1) in neuronal migration and development
|
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ErbB1 downstream signaling
|
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VEGFR1 specific signals
|
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Regulation of cytoplasmic and nuclear SMAD2/3 signaling
|
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Calcium signaling in the CD4+ TCR pathway
|
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Signaling events mediated by VEGFR1 and VEGFR2
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Insulin-mediated glucose transport
|
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N-cadherin signaling events
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Cellular roles of Anthrax toxin
|
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Regulation of Ras family activation
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Downstream signaling in naï
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PathWhiz Pathway
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Muscle/Heart Contraction
|
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Reactome
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Calmodulin induced events
|
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Platelet degranulation
|
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Translocation of GLUT4 to the plasma membrane
|
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Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
|
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DARPP-32 events
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eNOS activation
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Inactivation, recovery and regulation of the phototransduction cascade
|
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FCERI mediated Ca+2 mobilization
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Ca2+ pathway
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CREB phosphorylation through the activation of CaMKII
|
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Ras activation uopn Ca2+ infux through NMDA receptor
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Smooth Muscle Contraction
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VEGFR2 mediated vascular permeability
|
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VEGFR2 mediated cell proliferation
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RHO GTPases activate IQGAPs
|
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RAF/MAP kinase cascade
|
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Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
|
|
WikiPathways
|
Translocation of GLUT4 to the Plasma Membrane
|
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Visual phototransduction
|
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Fc epsilon receptor (FCERI) signaling
|
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Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
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Signaling by the B Cell Receptor (BCR)
|
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Inositol phosphate metabolism
|
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DAG and IP3 signaling
|
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Opioid Signalling
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Muscle contraction
|
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Metabolism of nitric oxide
|
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Metabolism of carbohydrates
|
| References |
| REF 1 | Appropriate dosing of antiarrhythmic drugs in Japan requires therapeutic drug monitoring. J Clin Pharm Ther. 2005 Feb;30(1):5-12. |
|---|
| REF 2 | Aprindine inhibits calmodulin-stimulated phosphodiesterase and Ca-ATPase activities. J Cardiovasc Pharmacol. 1983 Jan-Feb;5(1):151-6. |
|---|
