Drug Information
Drug General Information | |||||
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Drug ID |
D0W7GH
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Former ID |
DIB006773
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Drug Name |
IC-747
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Synonyms |
LFA-1 antagonists, ICOS/Biogen
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Indication | Psoriasis [ICD9: 696; ICD10:L40] | Discontinued in Phase 2 | [547348] | ||
Company |
ICOS Corp
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Structure |
Download2D MOL |
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Canonical SMILES |
S(c1c(cc(cc1)Cl)Cl)c1c(cc(N)cc1)Cl.Cl
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CAS Number |
CAS 300808-34-8
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Target and Pathway | |||||
Target(s) | Lymphocyte function-associated antigen 1 | Target Info | Antagonist | [551183] | |
KEGG Pathway | Rap1 signaling pathway | ||||
Cell adhesion molecules (CAMs) | |||||
Natural killer cell mediated cytotoxicity | |||||
Leukocyte transendothelial migration | |||||
Regulation of actin cytoskeleton | |||||
Malaria | |||||
Staphylococcus aureus infection | |||||
HTLV-I infection | |||||
Epstein-Barr virus infection | |||||
Rheumatoid arthritis | |||||
Viral myocarditis | |||||
NetPath Pathway | TCR Signaling Pathway | ||||
RANKL Signaling Pathway | |||||
Pathway Interaction Database | Integrin family cell surface interactions | ||||
Beta2 integrin cell surface interactions | |||||
CXCR3-mediated signaling events | |||||
References |
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