Drug Information

Drug General Information
Drug ID
D0W5OV
Former ID
DIB010378
Drug Name
DF-1111301
Synonyms
2-[2-(Dimethylamino)ethyl]-1-(2-ethoxyethyl)benzimidazole dihydrochloride
Indication Allergy [ICD9: 995.3; ICD10:T78.4] Discontinued in Phase 1 [545558]
CAS Number
CAS 127842-07-3
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Antagonist [531635], [550948]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 545558Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003701)
Ref 531635Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.
Ref 550948US patent application no. 2007,0196,421, Soft tissue implants and drug combination compositions, and use thereof.

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