Drug Information

Drug General Information
Drug ID
D0W5IN
Former ID
DNC012045
Drug Name
(2-Methyl-indol-1-yl)-propyl-pyridin-4-yl-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534087]
Structure
Download
2D MOL

3D MOL
Formula
C17H19N3
Canonical SMILES
CCCN(C1=CC=NC=C1)N2C(=CC3=CC=CC=C32)C
InChI
1S/C17H19N3/c1-3-12-19(16-8-10-18-11-9-16)20-14(2)13-15-6-4-5-7-17(15)20/h4-11,13H,3,12H2,1-2H3
InChIKey
JCEBKNUYKMFQGZ-UHFFFAOYSA-N
PubChem Compound ID
10515839
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Inhibitor [534087]
Alpha-2B adrenergic receptor Target Info Inhibitor [534087]
Alpha-2A adrenergic receptor Target Info Inhibitor [534087]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
GPCR downstream signaling
References
Ref 534087J Med Chem. 1996 Jan 19;39(2):570-81.Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.
Ref 534087J Med Chem. 1996 Jan 19;39(2):570-81.Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.